INFLUENCE OF GENETIC COPY NUMBER VARIANTS OF THE HUMAN GLUT3 GLUCOSE TRANSPORTER GENE SLC2A3 ON PROTEIN EXPRESSION, GLYCOLYSIS AND RHEUMATOID ARTHRITIS RISK: A GENETIC REPLICATION STUDY

Objectives: The gene encoding glucose transporter 3 (GLUT3, SLC2A3) is present in the human population at variable copy number.An overt disease phenotype of SLC2A3 copy number variants has not been reported; however, deletion of SLC2A3 has been previously reported to protect carriers from rheumatoid arthritis, implicating GLUT3 as a therapeutic tar

At the beginning of this century, debates regarding what are the main control mechanisms that ignite the action potential (AP) in heart pacemaker cells dominated the electrophysiology field.The original theory which prevailed for over 50 years had advocated that the ensemble of surface membrane ion channels (i.e., M clock) is sufficient to ignite r

The paper describes the results of the parametric analysis obtained using the multibody systems.Numerical analysis allows checking different variants of the weapon without the need of building a lot of experimental models.As a part of the analysis, the impact of the slide mass, the recoil spring stiffness, the friction coefficients, the propellant

The Trophic Cascade Theory has been used to explain the organization of herbivorous insect communities in tropical ecosystems.In addition, the insect community associated with a species of plant can also be determined by the geographical distribution and taxonomic isolation of the plant.In this study, the following predictions about the number of h